METABOLISM OF ESSENTIAL FATTY ACIDS

Metabolism of Essential Fatty Acids

The fat deficiency disease in the rat (I), dog (2), and chick (3) is characterized in part by sharply increased concentrations of one or more trienoic acids in the tissues, as indicated by alkali isomerization analyses. Indeed, the increase in conjugatable triene in the mitochondrial fatty acids may be the first noticeable symptom of the onset of fat deficiency (4). The major triene component o...

Consequences of Essential Fatty Acids

Essential fatty acids (EFA) are nutrients that form an amazingly large array of bioactive mediators that act on a large family of selective receptors. Nearly every cell and tissue in the human body expresses at least one of these receptors, allowing EFA-based signaling to influence nearly every aspect of human physiology. In this way, the health consequences of specific gene-environment interac...

Myocardial metabolism of fatty acids.

The myocardium is able to utilize both carbohydrates and noncarbohydrates for the performance of its work (1). Extraction of an individual substrate is usually determined by its arterial level. Thus, after a carbohydrate meal the heart derives much of its energy from the metabolism of carbohydrates; however, in the fasting state myocardial energy production is dependent upon noncarbohydrates, p...

Intestinal metabolism of fatty acids.

1. The effect of concentration on the oxidation and incorporation into lipids of lauric acid and linoleic acid by rings of rat small intestine has been studied in vitro. 2. In the absence of glucose, the oxidation of lauric acid in the range 0.01-5.0mm showed a maximum at 0.1mm. In the presence of glucose the maximum was at 0.5mm. The oxidation of linoleic acid in the presence of glucose increa...

Essential fatty acids and inflammation.